San Mateo sits centrally on the Peninsula and serves as one of San Mateo County’s primary healthcare hubs, anchored by Mills-Peninsula Medical Center. El Camino Real is the city’s main medical corridor, supported by additional office inventory near the hospital campus and downtown. With more than 105,000 residents and a mature market offering everything from Class A buildings to more affordable second-generation space, San Mateo can support solo specialists, multi-provider groups, imaging centers, and other healthcare users.